Safety {#5} influences

• General product risks, market selection and user type
• Manufacturability risks
• Legal, industry and consumer safety standards
• All the validations test requirements and product claims
• Technology selection
• Development tools and processes
• Design of product and documentation
• All test and production processes
• Facility, environment and worker protection and processes
• Product setup, installation, calibration processes
• Training and service
• Supplier selection
• Good will
• Liability, insurance accommodation and product failure
• Environmental issues, energy consumption
• Consumable management and inspection processes
• End-of-Life requirements and procedures

For example, if a product uses a consumable, but it presents a hazard to the consumer when replacing the consumable, this presents a highly litigious situation.  The danger also exists for production, training and service people.